Poster - #UMDOM118 - Basic and Translational Research

INFLAMMATORY CYTOKINES AND MICROBIAL LIGANDS AND METABOLITES INTERACT TO MODULATE DUOX2 EXPRESSION AND ACTIVITY

Hazime H, Fritsch J, Santander AM, Brito N, Fernández I, Pignac-Kobinger J, Conner GE, Abreu MT, Burgueno JF.

University of Miami

ABSTRACT
Inflammatory bowel diseases (IBD) is characterized by the development of inflammation and dysbiosis. Dysbiosis in IBD involves an expansion of Proteobacteria and a reduction of butyrate-producing Firmicutes. The epithelial NADPH oxidase dual oxidase 2 (DUOX2), which prevents bacterial colonization of the mucosa through the production of hydrogen peroxide, is the only gene consistently altered in early onset IBD. We aimed to define how inflammation and the microbiota regulate DUOX2 activity.